Global Commercial Strategy (GCS): Senior Manager, Early GI, Rheumatology, and Neurology

Why Patients Need You

Everything we do, every day, is driven by an unwavering commitment to the patients, healthcare providers, and customers who depend on us. In Global Commercial Strategy (GCS), we translate science of R&D into value for patients and Pfizer — from early development through launch, growth, and LOE lifecycle. GCS serves as the strategic engine and commercial voice across the asset lifecycle — shaping asset positioning and evidence generation, leading global launches, and driving sustained access and brand performance through market and payer insights, broad access, & commercial rigor. We take pride in shaping how innovative medicines reach the people who need them most, and ensuring they are accessible, understood, and valued across every market. Our success is anchored in the following Pfizer Blueprint values: Science, Technology, Transformation and Colleagues. Whether you are defining strategy, managing brands at different lifecycle, or building the capabilities that power our commercial engine, your work directly shapes patient outcomes and the long-term success of Pfizer's portfolio.

Role Summary:

The Senior Manager, Early Commercial Rheumatology, GI, and Neurology is a key role within the Inflammation & Immunology (I&I) Early Commercial Business, part of the Global Commercial Strategy organization, reporting to the I&I Disease Area Lead. This role will include contributing to long-range commercial strategy, disease-area portfolio prioritization, early commercial assessments, and investment decision support across Rheumatology, GI, and Neurology priorities within the I&I portfolio.

The broader I&I and Rare Disease portfolio represents significant strategic value to realizing Pfizer's vision to achieve leadership via breakthroughs in prioritized diseases and biological axes, with the goal of generating highly differentiated, multi-indication mega-blockbusters. Today, the portfolio delivers more than $10B globally, with 22 ongoing clinical studies underway to significantly expand the product portfolio over the next several years. This role will help translate that ambition into clear disease-area strategies, disciplined portfolio choices, and integrated commercial plans that maximize patient impact and enterprise value.

This leader will serve as the asset-level commercial voice for a subset of the assigned disease areas, bringing scientific depth, commercial judgment, and enterprise perspective to shape early development choices, product concepts, external innovation opportunities, and future value creation. The Senior Director will partner closely with R&D, Medical Affairs, Global

Access Strategy & Pricing (GASP), Business Analytics & Insights, Competitive Intelligence, Business Development, and US and International Commercial teams to translate scientific, clinical, market, access, and competitive insights into clear portfolio recommendations and actionable strategic choices.

This role requires a commercial strategist who can operate across ambiguity, influence senior cross-functional stakeholders, and advance disciplined trade-off decisions, long-range portfolio thinking, and AI-enabled ways of working in support of patient impact and enterprise value realization.

Responsibilities:

Disease Area Strategy and Long-Range Planning:

· Support development of long-range commercial and portfolio strategy across a subset of Rheumatology, GI, and Neurology disease areas, spanning early pipeline assets, lifecycle opportunities, external innovation, and emerging disease-area opportunities.

· Support generation of integrated near-, mid-, and long-term views of disease-area opportunities, risks, and investment priorities to inform portfolio decision-making.

· Synthesize scientific, clinical, commercial, access, competitive, and patient insights to identify priority opportunities and strategic trade-offs.

· Monitor shifts in the scientific and competitive landscape to identify emerging trends, market discontinuities, and implications for future I&I strategy.

· Translate disease-area strategy into clear recommendations, implications, and decision materials for leadership, governance forums, and cross-functional portfolio discussions.

Portfolio Prioritization and Investment Decision Support:

· Provide commercial leadership for portfolio prioritization, investment choices, and development opportunities across assigned disease areas.

· Pressure-test commercial assumptions, value drivers, risks, uncertainties, and evidence needs that may influence future launch potential, lifecycle value, and portfolio performance.

· Lead development of executive-ready materials that communicate strategic rationale, opportunity attractiveness, trade-offs, and recommended actions.

· Partner with cross-functional leaders to align on key choices related to indication sequencing, evidence generation, market development, and lifecycle opportunities.

· Support disciplined decision-making by ensuring assigned disease-area recommendations are grounded in patient need, scientific opportunity, market potential, access dynamics, and enterprise value.

Early Commercial Assessment and Product Concept Development:

· Lead early commercial assessments for pipeline assets, mechanisms, indications, disease-area opportunities, and potential future product concepts across assigned areas.

· Develop and refine product concepts, target product profiles, positioning hypotheses, market archetypes, commercial opportunity assessments, and forecast assumptions.

· Ensure unmet need, standard of care, competitive dynamics, patient/HCP insights, and access considerations are translated into differentiated commercial hypotheses.

· Provide commercial input to clinical development, evidence generation, lifecycle, and indication sequencing discussions in partnership with cross-functional colleagues.

· Build repeatable approaches for high-quality early commercial strategy outputs across the team.

Business Development and External Innovation Support:

· Lead commercial strategy input for external innovation and Business Development opportunities relevant to assigned disease areas.

· Guide assessment of strategic fit, market potential, valuation inputs, competitive scenarios, and portfolio implications for potential external opportunities.

· Partner with Business Development, R&D, GASP, BAI, and Competitive Intelligence colleagues to pressure-test assumptions and identify key decision points.

· Represent the commercial perspective in internal discussions related to external opportunities and broader disease-area strategy as needed.

Cross-Functional Leadership, Governance, and Team Development:

· Influence without direct authority by aligning stakeholders around shared insights, strategic choices, and implications for the I&I portfolio.

· Build trusted working relationships across R&D, Medical Affairs, GASP, BAI, Competitive Intelligence, Business Development, and Commercial Regions.

· Foster a culture of enterprise thinking, scientific curiosity, accountability, collaboration, and talent development within the team.

AI-Native Ways of Working:

· Set expectations for responsible, AI-enabled ways of working across the team to improve speed, quality, consistency, and scalability of portfolio strategy outputs.

· Champion use of AI-enabled tools to support scientific and competitive landscape synthesis, market insight generation, scenario development, and decision-support efficiency.

· Identify opportunities to embed AI into repeatable workflows, templates, portfolio reviews, and strategic decision-support processes.

· Use performance insights, stakeholder feedback, and team learnings to continuously improve AI-enabled ways of working across assigned disease areas.

Qualifications:

Basic Qualifications:

· Bachelor's degree required; MBA or advanced degree preferred.

· 6+ years with a BA/BS, 5+ years with MBA/MS, 1+ years with PhD or JD of experience in pharmaceutical, biotechnology, life sciences, commercial development, portfolio strategy, corporate strategy, business development, market research, forecasting, analytics, or related field.

· Strong strategic and analytical skills, with ability to synthesize complex scientific, clinical, market, access, and competitive information into clear recommendations.

· Experience leading early commercial assessment, business case development, opportunity assessment, or cross-functional strategic planning.

· Ability to engage in scientific and clinical dialogue and translate implications for commercial opportunity, differentiation, portfolio value, and enterprise decision-making.

· Strong communication, executive presence, problem-solving, and stakeholder management skills.

Preferred Qualifications:

· Advanced degree in business, life sciences, public health, medicine, pharmacy, or related field preferred.

· Experience in Rheumatology, GI, Neurology, I&I, specialty care, or other complex therapeutic areas preferred.

· Experience with commercial development, early asset strategy, portfolio management, Business Development assessments, forecasting, valuation, or investment prioritization.

· Demonstrated ability to develop long-term strategies for products or disease areas and secure alignment from senior leadership.

· Understanding of market access dynamics, payer considerations, evidence generation, value demonstration, and lifecycle value optimization.

· Track record of leading cross-functional teams, influencing without authority, and making recommendations with incomplete information.

· Comfort working in an AI-native or AI-augmented environment; experience using AI tools to support strategy, synthesis, or analysis is a plus.

· Ability to thrive in ambiguity, operate with enterprise mindset, and adapt to evolving portfolio priorities.

· Discretion, sound judgment, and trustworthiness in handling confidential or sensitive organizational matters.

Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.

Work Location Assignment: Hybrid

Other Job Details:

Last day to apply: November 12, 2026

The annual base salary for this position ranges from $124,400.00 to $207,400.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 17.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
This role is posted in multiple locations. If you are applying for the role in an secondary job posting location where pay transparency regulations apply, your Talent Advisor will share the local pay information with you during the first interview.



Relocation assistance may be available based on business needs and/or eligibility.

Candidates must be authorized to be employed in the U.S. by any employer.

U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

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