Scientist, Analytical and Biological Mass Spectrometry (ABMS)

Build our future together:

At Regeneron, we use science and innovation to develop life-changing medicines for people with serious diseases. We are seeking a highly motivated Scientist to join our Analytical and Biological Mass Spectrometry (ABMS) team in support of Regeneron R&D programs. In this role, you will work in a collaborative mass spectrometry laboratory focused on the biochemical characterization of emerging therapeutic modalities and monoclonal antibodies across all stages of development.

This position offers an opportunity to contribute to a fast-growing, science-driven organization while learning through hands-on project work and making a meaningful difference for patients worldwide.

When & where:

• Full-time position based at Regeneron’s Tarrytown headquarters
• Requires a minimum of four days per week onsite

Discover your role:

• Develop and optimize primarily LC-MS-based analytical methods to support diverse R&D programs, applying sound scientific judgment and demonstrating a clear understanding of the methods and experiments performed
• Analyze and interpret LC-MS data using appropriate software and bioinformatics tools to characterize the quality attributes of therapeutic proteins and emerging modalities
• Support R&D activities and regulatory submissions while expanding organizational knowledge of antibody therapeutics and other emerging modalities
• Independently perform sample preparation and LC-MS-based experiments according to SOPs, and document experiments, results, and conclusions in electronic laboratory notebook (ELN) entries
• Present data at group and project meetings, and prepare technical reports, SOPs, and regulatory submission documents
• Summarize results clearly and concisely using graphs, figures, and tables to support presentations, peer-reviewed publications, and regulatory documents
• Communicate with integrity, honesty, and respect in written and verbal interactions; contribute openly to scientific discussions and raise questions or concerns when appropriate
• Take ownership of experimental work, openly discuss unexpected results, identify root causes, and make timely corrections while maintaining accurate and transparent records
• Learn new technologies and scientific concepts through active participation in projects, collaboration with colleagues, and constructive feedback, while contributing enthusiastically in a team environment

This role requires:

• BS or MS (or higher) in chemistry, biochemistry, analytical chemistry, pharmaceutical sciences, metabolism, or a related field
• 6–8+ years of industrial or academic experience in the analytical characterization of small molecules, antibodies, protein therapeutics, AAVs, metabolites, lipids, or other therapeutic modalities
• Knowledge of and hands-on experience with LC-MS-based sample preparation for cells, tissues, biological matrices, and drug substances
• Strong knowledge of metabolism and hands-on experience in metabolomics or lipidomics are highly desirable; experience with metabolic flux analysis, isotope tracing, or related quantitative approaches is a plus
• Knowledge of pharmaceutical formulation and process development is a plus
• Knowledge of and experience in AAV virology, siRNA, and structural biology are a plus
• Experience with automated liquid-handling systems (Biomek, Bravo, KingFisher, Tecan, or similar platforms) is a plus
• Experience with specialized LC-MS-based techniques, such as hydrogen-deuterium exchange mass spectrometry (HDX-MS), ion mobility spectrometry-mass spectrometry (IMS-MS), and quantitative proteomics, is a plus
• Experience with experimental design and data analysis, including design of experiments (DoE), molecular modeling, graphing, statistical analysis, or quantitative pathway and flux analysis software, is a plus

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.

Where necessary, we disclose salary ranges for roles in all countries in which we operate. The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits. Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits. For additional information about Regeneron benefits in the U.S., please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/. For other locations, additional information will be provided during the recruitment process. If you have any questions, please speak with your recruiter.

Please be advised that at Regeneron, we believe we do our best work when we are together. For that reason, many roles are required to be performed on‑site. Please speak with your recruiter and hiring manager for more information about on‑site expectations for your role and location.

As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications.

For jobs in Canada: this posting is for an existing position.

Salary Range (annually)